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Cystic fibrosis (Causes (In early childhood the thick mucus secretion will…
Cystic fibrosis
Causes
In early childhood the thick mucus secretion will jam the pancreatic duct causing less pancreatic fluids to get excreted. This causes poor weight gain, failure to thrive, Steotorrhea (fat in the stool) and pancreatic damage and inflammation due to backed up enzymes (acute/chronic pancreatitis).
In new born this can cause a thick meconium (first stool) making it hard to excret. This is a surgical emergency.
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Nasal polyps (tissue growth in nose)/ Sinusitis (frontal headaches, nasal congestion)
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Liver disease (focal biliary cirrhosis (hardening), fatty infiltration, can lead to cirrhosis)
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Caused by a mutation in the Cystic Fibrosis Trans-membrane Conductance Regulator (CFTR). These genes control the Chloride channels that control the movement of water in and out of the cells. Due to the decreased amount of chloride that travels to the outside of the cell there will be a a thicker amount of mucus. There are 6 types of CFTR mutations:
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Dianosis
In newborns
Detection of pancreatic enzyme IRT (Immuno reactive trypsinogen) which is released into the blood when pancreas damage occurs.
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