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0 bacteremia (bacteremia ((cold, shivering, fever, vomiting),…
0 bacteremia
bacteremia
cold, shivering
fever, vomiting
muscle/joint pain
pale/mottled skin
coagulation
DIC: consumptive coagulopathy
ARDS: diffuse alveolar damage
endothelial injury
sepsis + hypoperfusion
severe sepsis
Systemic Inflammatory Response Syndrome
2 or more
HR >90
temp <36, >38
respi >20, PaCO2 <32
WBC <4000, >12000, >10% band
infection + SIRS
sepsis
severe sepsis + hypotension
septic shock
prostaglandins leukotrienes
multiple organ dysfunction syndrome
heart, lungs
GI, liver, kidneys
CNS, skin
complement
thrombosis permeability vasodilation: shock
antigen from bacteria
endotoxin
pro-inflammatory cytokines