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Renal Pathology (Nephrotic (Membranous Nephropathy (subepithelial…

- - - - abrupt onset of hematuria and proteinuria with reduced GFR and renal salt and water retention
      - infectious disease
      - tissue injury caused by complement activation by classical pathway
      - Rapidly Progressive glomerulonephritis
        
        at least 50% glomerular filtration failure
        
        "crescentic GN" -- cellular crescents in bowman space formed in response to severe damage to glomerular capillaries limited to kidney
        
        antiglomerular basement membrane antibody disease
        
        caused by development of circulating antibodies to an antigen intrinsic to glomerular basement membrane
        
        binding of pathologic anti-GBM antibodies to glomerular basement membrane causes inflammation
        
        linear deposits of IgG
        
        Anti-neutrophil cytoplasmic antibody (ANCA)
        
        lack of anti-GBM antibodies or of significant immune complex deposition
        may be renal or systemic
        
        found in serum
        
        crescentic GN
        
        Immune complex glomerulonephritis
        
        granular immunoglobulin deposits suggestive of immune complexes from systemic disease
        
        Ex. post infectious GN where there is cross reactivity between antigen of infecting organism and host antigen and results in deposition of immune complexes and complement in glomerular capillaries
    - - persistent urinary abnormalities, slowly progressive decline in renal function
      - does not resolve
      - Cellular Proliferation in either mesangium or capillary
      - obliteration of glomeruli
  - - - Immune complex disease with mesangial IgA deposition