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NMJ redox biochemistry (No NOX (Preserve O2, Relates to EcSOD, No O2.-…
NMJ redox biochemistry
No NOX
Preserve O2
Relates to EcSOD
No O2.- into synaptic cleft "phagosome hypothesis"
consumes NADPH
synaptic cleft
oxidising
Limited escape for O2.-
Small, diffusion distance for H2O2 and NO
limtied for ONOO derived radicals
membrane rich
NO stop peroxidation
link to ferroptosis
ONOO
Source of oxidising radicals
NO
nNOS PSD and muscle
Limited space and resource
mitochondria
O2.-/H2O2
MnSOD, CuZnSOD
PRXD3/5
GPX1 GPX4
NADPH
nucleotides