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BIOACTIVE GLASSES (Drug Delivery (Future trends (Improve load bearing…
BIOACTIVE GLASSES
Uses
Dental implants
Coating of Ti implants
Middle ear devices and implants
Bioglass :star:
Material classification
for bone
Osteoconduction
Osseointegration
Osteoinduction
Calcium Phosphate
Bioceramics
High affinity and activity
Hydroxyapatite
No soluble in water
Brittle
Can't use as bulk material
Used as coating
Plasma spraying
Surface protective barriers
Carrier system
Promote rapid fixation of devices to skeleton
Also used as powders, porous blocks or beads to fill
Bone substitute
Substitutions
Replacing Ca2+
Replacing OH-
Hierarchy
Synthetic HA: Ca/P=1.67. through precipitation
Tricalcium phosphates
Beta-TCP ideal for bone subs → excellent biocompatibility and bioresorbility → bone and tooth implant
Cannot be used as bulk material
Resorption rate proporcional to Ca/P ratio
50/50 HA and Beta-TCP best for MSC attachment and proliferation
Drug
Delivery
Porous ceramic
scaffolds
or bone TE
Porosity and interconnectivity are critical
Need balance between porosity
and mechanical properties
Future trends
Provide signals to cells
Understand fundamentals of bone
Increase Flexibility
Bioactive + Biodegradable
Improve load bearing capacity
Incorporate tougher Polymers to ceramics scaffold
Mimicking bone structure
Calcium Phosphate
Co-precipitation taken up by cells
Dissolve in acidic environments, increase osm P
Inert, non toxic
Prone to variability and small changes
Ceramics have high affinity for drugs and growth factors :star:
Gene delivery :star: