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Dementia (Age>50 (Alzheimer's (Cholinesterase inhibitors (Donepezil…
Dementia
Age>50
Alzheimer's
Cholinesterase inhibitors
Donepezil
Galantamine
Rivastigmine
NMDA antoagonist
memantine
-dementia followed by bradykinesia/rigidity
-visual hallucination
-syncope
Lewy Body Dementia
Bradykinesia/rigidity followed by dementia
Parkinson's
-Stepwise decline in cognitive function
-H/o vascular disease
Vascular Dementia
-Liver disease followed by dementia
-Kayser-Fleischer Rings
Wilson's Disease
Age<50
Rapidly-progressive
Myoclonus
CSF with 14-3-3 protein
Creutzfeldt-Jacob disease
Choreoform movement
+Family history (AD)
MRI with atrophy of caudate/putamen
Huntington's Disease
Supportive care
Tetrabenazine
Any Age
B12
TSH
Sexual Hx (+/- HIV/RPR)
Low B12
Megaloblastic anemia
Loss of vibratory sensation
B12 deficiency
Elevated TSH
Weight gain, etc.
Hypothyroidism
Normal B12, TSH
Urinary incontinence
Wide-based gait
MRI with enlarged ventricles
Normal Pressure Hydrocephalus
Ventricular shunting
HIV or neurosyphilis
Work up should include: B12, TSH, CBC, CMP, MRI/CT brain, +/- RPR & HIV