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Anti-depressant (Typical anti-depressant (Tricyclic (imipramine…
Anti-depressant
Typical anti-depressant
Tricyclic
imipramine
desipramine
clompramine
trimioramine
amitriptyline
nortriptyline
protriptynline
doxepine
tetracyclic
maprotiline
amoxapine
inhibition of neurotransmitter reuptake that causes increase of monoamine in synaptic cleft
blocking of serotgenic-a-adreniergic histaminic receptor
this causes the adverse effects of this type like
arrhythmia
dry mouth
sexual dysfunction
weight gain
serotonin-norepinephrine reuptake inhibitors
Venlafrine, Desvenlafaxine, Dulaxetine
inhibit reuptake of sertonin-norepinphrine .
Vanlafaxine and desvenlafaxine at high doses cause elevation of BP and HR
Duloxetine isn't taken with hepatic insufficincy
Selective serotonin reuptake inhibitor
fluoxtine, paroxtine, sertialine, citalopram
inhibit seotonin reuptake
side effects of TCA not common here
monoamine oxidase inhibitors
Phenelzine, Tranylcypromine, Isocarboxized
irreversible inactivation of MAO so the neurotransmitter will increase within presynaptic
types of MAO inhibitor
for MAO-A is moclobernide
for MAO-B Selegiline
side effects
selegiline and tranylcypromine have amphatonin like effects
serotonin syndrome
dry mouth and orhostatic hypotension
atypical anti-depressant
bupropion
weak dopamine and norepinphrine reuptake inhibitor
side effects : dry mouth and seizures at higher dose
Mirtazapine
enhance serotonin and norepinephrine by blocking presynaptic alpha2 receptor
Nefazodone, Trazodone
weak inhibitor of serotonin reuptake
Tianeptine
decrease the availability of serotonin
Mania and Bipolar disorder
lithum
dry mouth and ataxia
electroconvulsive therapy