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four statin benefit group (4- Individuals with out clinical ASCVD or DM…
four statin benefit group
4-
Individuals with out clinical ASCVD or DM & aged 40- 75 yrs wz 10-year ASCVD risk ≥7.5%
If a patient without high-risk markers
moderate intensity statin
If a patient with high-risk markers :!!:
high intensity statin
consider steps1-3
ezetemibe first choice,BAS second choice. PCSK-9 inhs are not considered here
3-
Individuals aged 40 -75 yrs with DM & LDL-C 70-189 mg/dL
with 10-year ASCVD risk <7.5% and without high-risk features
moderate intensity statin
consider steps1-3
ezetemibe first choice,BAS second choice. PCSK-9 inhs are not considered here
wZ 10-year ASCVD risk >7.5% and with high-risk features :!:
high intensity statin
1-
clinical ASCVD
:red_flag:
< 75 years
high intensity statin
consider steps1-3
ezetemibe first choice,BAS second choice. PCSK-9 inhs third choice.PCSK-9 inhs may be considered considered before BAS if LDL-C >190 mg/dl
above 75 years
moderate intensity statin
2- Individuals w 1ry elevations of LDL–C ≥190 mg/dL not due to 2ry causes.:red_flag:
high intensity statin
consider steps1-3
ezetemibe first choice,BAS second choice. PCSK-9 inhs may be considered considered before BAS.
hoFH: consider lomitapide, mepomersan or LDL-C apheresis