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ENZYMES (Enzymes (Catalysts (induced fit :!: (change shape to accommodate…
ENZYMES
Enzymes
Protein
20 amino acids
peptide bonds
aid by acting as
nucleophiles
acid/base catalysts
Catalysts
lowering the activation ernegy
induced fit :!:
change shape to accommodate Substrates
max the bonding forces
Subtrates (S)
undergo ezyme-catalyze
in ideal
conformation
may (not) be the most stable :warning:
position
Binding to
Substrate (S)
Products (P)
Active site
Protein surface
hollow / cleft
bonding
hydrogen
ionic
van der Waals
dipole-dipole
Enzyme Inhibitors
inhibit catalytic act of an enzyme : :star:
competitive Inhibitors
compete
natural substrates
for Active sites
can be
irreversible
reversible
noncompetitive Inhibitors
not compete
natural substrates
for Active sites
bind to
Allosteric site
induced fit
change shape
no recognizable to substrates
can be
irreversible
reversible
Mechanism of Catalysis
Enzyme Selectivity
