Please enable JavaScript.

Coggle requires JavaScript to display documents.

Inhibition (irreversible inhibitors (cause damage to enzyme, do not have…

- - - - compete for the same active site (direct competition)
      - inhibitor bind to the active site, prevent substrate bind to the enzyme, enzyme-substrate complex does not form, no product, reduce the rate of rxn
      - similar shape with substrate
      - to decrease the effect of inhibitors, decrease the [inhibitors], increase[substrate],more chance to bind to the active site
      - eg. malonate( compete with succinate for the enzyme succinate dehydrogenase)
    - - do not compete with the same active site with substrate
      - inhibitor binds to allosteric site causing change of conformational active site,substrate cannot bind to active site,enzyme-substrate complex does not form, product do not form
      - do not have similar shape with substrate
      - decrease [substrate] does not affect the rate of rxn because non-competitive inhibitor and substrate do not compete for same active site
      - eg. isoleucine,ATP
      - end product inhibition: the final product in one biochemical pathway becomes inhibitor when its concentration too high