Please enable JavaScript.
Coggle requires JavaScript to display documents.
Byne et. al (2001) (Method (Volumetric Analysis: Sexual Influence on INAH3…
Byne et. al (2001)
Method
Participants
HIV(+) and HIV(-) presumed heterosexual males and females
HIV (+) presumed homosexual men
Volumetric Analysis: Affect of HIV on INAH1
Only INAH1 revealed a significant influence of HIV status: Volume increased by ~8% in HIV (+) males and females
Volumetric Analysis: Sexual Influence on INAH3
No significant influence of HIV
Volumetric analysis of heterosexual male, heterosexual female, and homosexual male subjects.
Size of INAH3 in homosexual males was intermediate between heterosexual males and heterosexual females; differences did not reach statistical significance to either group.
Brain Weight Analysis: INAH3
Brain volume/weight INAH3: Significant main effect of sex but NOT HIV.
Failed to demonstrate a significant difference between homosexual men and heterosexual men or women
However, there was a trend for homosexual male INAH3 weight to be reduced compared to heterosexual males
INAH3 Neuronal Volume and Density: Significant Group Effect
Heterosexual Males: Larger volume; lower neural density
Homosexual Males: Lower volume; greater neural density
Discussion Points
INAH3 in heterosexual men and women
Sexually dimorphic: INAH3 occupies more volume and contains more neurons in presumed heterosexual men than women.
INAH3 Neuronal Number
Did NOT vary as a function of sexual orientation
Resemblance of human INAH3 to homologous SDN-POA in rats
Positional characteristics
Cytoarchitectonic characterisics
INAH3 in heterosexual and homosexual men
Heterosexual men = larger volume
No difference in INAH3 neural number
Difference in volume between groups accounted for by neural density of INAH3; heterosexual men = lower neural density; homosexual men = greater neural density
Overall Summary (Interstitial Nuclei of the Anterior Hypothalamus
Sexual dimorphism in INAH3, but no other INAH
Heterosexual males: larger volume
Heterosexual females: smaller volume
Trend for INAH3 to occupy a smaller volume in homosexual men compared to heterosexual men.
No difference in the number of neurons within the nucleus based on sexual orientation in men.
INAH3 is dimorphic in both:
Sex
INAH3 larger in presumed heterosexual males
Smaller in presumed heterosexual females
Sexual orientation
INAH3 Smaller in presumed homosexual men
INAH3 size in presumed homosexual men is similar to presumed heterosexual women