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Coronary Heart Disease (Risk Factors (Lifestyle (Managing Risk (LIfestyle,…
Coronary Heart Disease
Etiology/Patho
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- Inexorable increase in size of the plaque such that it may acutely decrease blood flow for a given demand on the heart
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- Acute rupture of an unstable plaque, regardless of the size of the plaque
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Risk Factors
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New and emerging (proteomics, metabolomics, other -omics
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ISCHEMIC HEART DZ
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Symptoms
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Diaphoretic, ongoing, w/o current exertion
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Other "anginal" symptoms
SOB, w/ less exertion than normal
Dyspnea: intense tightening of chest, air hunger, feeling of suffocation
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Testing
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biomarkers: troponin, ck, ckmb
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Results
NSTEMI: Neg EKG for ST elevation, Pos biomarkers for cardiac injury
USA: Neg EKG for ST elevation, Neg biomarkers for cardiac injury
Tx
Anti-anginals:
Post MI, Post ACS
NItrates
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Isosorbide mononitrate (Imdur, Ismo)
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Indication
Acute angina: ACS, provoked CSA
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