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sle (diagnostic criteria requires 4 or more of 11 signs/ symptoms (skin…
sle
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managment
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minor symptoms: NSAIDs, low-dose steroids, anti-malarials
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Aetiology
mixture of environmental and genetic factors- genetic susceptibility leads to impaired clearance of apoptotic cells and of immune system to identify nuclear antigens as self.
oestrogen assoc - 10x more common in women then men in reproductive years
wheres in non reproductive yrs (childhood/ >65s) still women>men but no to same extent
general symptoms: malaise, fever, arthalgia
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development of autoantibodies involves a defect in apoptosis that causes increased cell death and a disturbance in immune tolerance. The defective clearance of the apoptotic cell debris allows for the persistence of antigen and immune complex production.
Onset of SLE is usually after puberty, typically in the 20s and 30s
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Type III hypersensetivity body has developed autoantibodies against body- involves multiple organs and often manifests with skin signs.
Signs and symptoms depend on where the auto antibodies are attackng e.g. if targeted at RBCs-> anaemia
