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ALPHA1- AND MIXED ALPHA/BETA-BLOCKERS Antihypertensive drugs belonging…

- - - - For HTN 1 mg at bedtime, may increase dosage to desired response but no more than 20 mg/day over a 12 h period.
        For BPH 1 mg at bedtime and gradually increase 5-10 mg
        (Skidmore-Roth, 2017, pp. 1129-1130).
    - - 10 mg/day, after meal
        (Skidmore-Roth, 2017, p. 34).
    - - For HTN 1 mg/day h.s. and increase up to 16 mg/day if necessary.
        For BPH 1 mg/day h.s. and increase in dosage of 2,4,8 mg at 1-2 wk intervals.
        (Skidmore-Roth, 2017, pp 397).
    - - 4 mg/day increasing to 0.8 mg/day if after 2-4 wk
        (Skidmore-Roth, 2017, p. 1113).
    - - 8 mg/day with meal. If Creatinine Clearance (CCr) is between 30-49 ml/min give 4 mg/day. <30 ml/min do not give
        (Skidmore-Roth, 2017, p. 1070).
    - - 1 mg BID/TID and increase to a maximum of 20 mg/day.
        For BPH 2 mg BID
        (Skidmore-Roth, 2017, pp. 963-963).
  - - - Tabs: 3.125mg, 6.25mg, 12.5mg, 25mg;
        ER capsules: 10mg, 20mg, 40mg, and 80mg; 6.25mg PO BID on instances of monitoring standing BP 1 hour after the first dose. If tolerated continue dosage for 7-14 days and may increase to 12.5mg PO BID for 7-14 days following same BP protocol. If tolerated well, may be increased (if needed) to 25mg bid; not to exceed 50mg/day; EXT REL cap 20mg/day, may increase after 7-14 days to 40 mg/day, max 80 mg/day
        (Wolters Kluwer, 2016, pp. 278-280).
    - - Injection: 5mg/mL in 20 and 40 mL multiple-dose vials;
        Direct IV route
        • Give slow over 2 min at 10 min intervals
        Continuous IV INF route
        • Diluted in D5W or NNS and use infusion pump; keep patient recumbent during and for 3 hr after administration; monitor VS q5-10min
        (Wolters Kluwer, 2016, pp. 810-812).
      - Tabs: 100mg, 200mg, 300mg;
        Adult inpatient: 200mg PO followed by 200 to 400mg PO in 6-12 hours depending on BP response. Increase dose maybe by 200mg PO BID.
        Adult outpatient: 100mg PO BID; with or without diuretic; may increase to 200mg BID after 2 days; may continue to increase q2-3 days; max 2400mg/day in divided doses
        (Wolters Kluwer, 2016, pp. 810-812).
- - - - BUN
- - - - Take first dose at bedtime
      - Avoid driving for 12-24 hours after first dose
  - - - Reinforce the need to continue additional therapies for hypertension
        (weight loss, sodium restriction, stress reduction, regular exercise, moderation
        of alcohol consumption, and smoking cessation). Medication controls but
        does not cure hypertension. (FDA, 2016).