Please enable JavaScript.

Coggle requires JavaScript to display documents.

Lymphocytes (Natural Killer Cells (lymphocyte like) (membrane receptors…

- - - - binding triggers perforin release which causes cytolysis
- - - - Intracellular pathogen defense, tumor immunity, graft rejection
      - Can kill by osmotic lysis, TNF secretion, apoptosis induction
  - - - TH1 cells
        
        enhance activity of CD8 cells, interferon and TNF
        
        Develop in presence of IL 12
        (secreted from activated macrophages)
        
        secrete cytokines that suppress other immune cells, putting the brake on immune responses "checks and balances"
        
        response: inflammation, autoantibody production Autoimmune diseases
        Immediate sneezing
      - TH2 cells
        
        Develop in presence of IL 4
        
        enhance antibody production, activate eosinophils; secrete IL4,IL5, and IL 13 for humoral responses
        
        respond to allergens and helminthes
      - TH17
        
        role in autoimmunity, inflammation
    - - modulate inflammation through cytokine secretion
      - TH17 boosts early phagocytic cell responses
      - High affinity receptors for IL-2 (CD25) and FOXp3 --> TF that suppress autoimmune disease
        Inhibits TH17 cells
- - - - Happens in the bone marrow
      - pre-B cells mature into immunoglobulin-bearing naive B cells
    - - Happens in Lymphoid tissues
      - Produces circulating long lived memory B cells and plasma cells