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Cirrhosis (Pathophysiology (Hepatic venous outflow obstruction, New…
Cirrhosis
Pathophysiology
Hepatic venous outflow obstruction
New vascular channels shunt blood flow away from liver due to portal hypertension
Prolonged exposure to alcohol or toxins
Toxin accumulation
Fatty liver disease
Ascites
Clinical Presentation
Janundice
Hepatic encephalopathy
Ascites
Portal hypertension
Anemia
Malnutrition
Risk Factors
Hepatitis virus B or C
Excessive alcohol intake
Idiopathic
Non-alcoholic fatty liver disease
Prolonged exposure to drugs and toxins
Hepatic venous outflow obstruction
Epidemiology
Those with low SES at higher risk
Racial/ethnic minorities are at higher risk
Approximately 1: 679 people in USA will get cirrhosis
Diagnosis and Treatment
Treatment
TIPS
Liver transplant
Supportive
Paracentesis
Better nutrition/nutritional support
Diagnosis
CBC
Liver biopsy
LFTs (AST and ALT
Serum albumin levels