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19F CRP problems (low SNR (B0 and B1 inhomogeneities (B1 mapping (How is…
19F CRP problems
low SNR
B0 and B1 inhomogeneities
B1 mapping
(How is the FA error?)
Double angle method (
DAM
)
long acquisition times
in vivo "unfriendly"
homogeneous phantom
with high TFE concentration
ex vivo
in vivo
(less PFC concentrations, movement, registration problems)
lower concentrations: use 1H images for B1 map?
Future improvements
Filtering of FA maps
use of acquired images "danger zone"
use of thresholded images
insights into sanlm algorithm
Gaussian smoothing
Validity investigation
Problems have been found for angles > 130°
Bruker method (??)
B1 correction
Account for
B1+
and
B1-
Use of
signal equations
complexity dependent on the sequence
sequence still not chosen
several parameters to take into account
high field (9.4 T)
no anatomical images
for registration (1H needed)
repeatable and reproducible positioning
for 1H and 19F CRPs
3D printer
markers
on the mouse / tube
in nano-tubes placed at certain position
possible holder in craddle?