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Viruses (Structure (Nucleic acid, Capsid, Envelope, , Need host cell to…
Viruses
Structure
Nucleic acid
Capsid
Envelope
Need host cell to replicate
Acellular
Viral Life Cycle
Synthesis
+ssRNA viruses
Retroviruses
Reverse transcription
Provirus
dsDNA
In host nucleus
Envelope
Penetration
Endocytosis
Fusion
Uncoating
Attachment
Attachment site on capsid
Spike protein on envelope
Assembly
Release
Lytic
Cell death
Persistent
Exocytosis
Latent
No release
Antivirals
Amantadine
#
Acyclovir
#
Nuceloside reverse transcriptase inhibitors
#
Protease inhibitors
#
Neurominadase inhibitors
#
Viral Infections
Acute
Influenza, HepA
Latent
Chicken pox -> Shingles
Chronic
HepB
Slow
prions
Classifications
Host
Tissues they attack
Nucleic acid
DNA viruses
Single-stranded
Double-stranded
ex.
Herpesvirus
can use host enzymes for replication
Linear DNA
#
Circular DNA
RNA viruses
Single-stranded
Positive-sense (+ss RNA)
acts as mRNA which can be directly translated by host ribosomes
ex. HIV
Negative-sense (-ss RNA)
acts as template for transcription
ex.
Influenzavirus
Double-stranded
ex.
Rotavirus
-> resp & GI infections
need to carry viral enzymes for replication
Viruses & Cancer
Inhibit tumour suppression genes
Promote oncogenes
Increase replication