Please enable JavaScript.
Coggle requires JavaScript to display documents.
Bone (Structure of Bone (BONE MATRIX
What bone is made of (LAMELLAR BONE,…
Bone
Structure of Bone
-
-
PERIOSTEUM
Thin sheath of connective tissue which covers outer surface except articular surfaces
Has Fibrous & Cellular Layer
-
-
Cartilage
Composed of chondrocytes & chondroblasts
They create a matrix of type II collagen & proteoglycans to bind water
-
-
Cell Types in Bone
OSTEOCYTES
Mature, relatively inactive osteoblasts that are engulfed within bone
-
-
-
-
-
Bones grow from cartilage by interstitial growth until epiphyseal fusion
Then bones thicken by appositional growth
This is growth in diameter of bone around the diaphysis
BONE REMODELLING
Bone is continually turned over by the combination of osteoclast activity & osteoblast activity replacing old bone tissue with new
RESORPTION
Create acidic environment to dissolve mineral content & secrete proteolytic enzymes to remove collagen from bone matrix
-
ACTIVATION
Osteoclastogenesis, Differentiation & Activation are mediated by M-CSF & RANKL
PTH stimulates OB to release RANKL
OB also release IL-1, IL-6 & TNF-α
-
-
Living fibrous tissue made rigid by calcium designed to withstand high compressive loads
The bone is laid down in the Haversian system
-