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Autoantibodies are produced with T and B cell activation (Leilani M) SLE…
Autoantibodies are produced with T and B cell activation (Leilani M) SLE
Coagulation proteins and plateletes
Thrombocytopenia
Bleedings
lymphocytes
Infection: fever (pneumonia)
Erythrocytes
anemia
fatigue
Immune complexes are deposited in parts of the body
Skin
Discoid lesions
round, coin shaped
Subacute cutaneous lupus
persistent lesions + photo-sensitivity + systemic disease
Butterfly rash
on nose and cheeks
scalp
alopecia: may or may not grow back
dry, scaly, atrophied
Mouth ulcers
Heart
dyrrhythmia (advanced)
endo/mayocarditis
Kideys: s&s by 5 years
lupus nephritis (LN)
increased protien release = hypercholesterolemia
protenurea and glomerulonephritis
KF
infertility
antiphospholipid syndrome
clots in blood
Risk for: stroke, MI, gangrene
Joints
polyarthralgia
Swann
ulnar deviation
subluxation with hyperlaxity
morning stiffness
diffuse swelling
joint pain
Risk for: osteoporosis and frature
Vessels
Hypertension
Brain
seizures
disorientation, poor memory, HA, anxiety, depression, psychosis, mood changes
GI
Nausea and vomiting
Diarrhea and abdominal pain
dysphagia
Lungs
tachypnea/cough
pleural effusion/pneumonitis
Signs of Exacerbation
severe fatigue
fever(careful that it is not infection)
arthragia/weight loss