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12-245 Part C Workflow ((Part-C Positive (Moderate Penetrant Positive (FH…

- - - - FH Positive
        
        Cosegregation
        Tumor LOH
        Fxnl study (Biopsy or resampling)
      - FH Negative
        
        Denovo
      - MPC
      - Early Onset
        
        Bladder EO (<45 yrs)
  - - - Functional Studies of VUS
      - MPC, Strong fam hx amenable to cosegregation, Extreme Phenotype, Early Onset
        
        Expanded Part C
        
        Expanded Part C Positive, (Treat as Part C Positive)
        
        FH Positive
        
        Cosegregation, Tumor LOH, Fxnl study
        
        FH negative
        
        De Novo
        
        Expanded Part C Negative
        
        If FH positive or extreme phenotype, then ascertainment, family expansion and Exome sequencing