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E5 thyroid ((metabolic rate, metabolic substrate, cardiovascular…
E5 thyroid
metabolic rate
metabolic substrate
cardiovascular respiratory
SNS
CNS, bone development
thyrotoxicosis
secondary
(TSH-secreting) pituitary adenoma
subacute
primary
adenoma
Graves
children: cretinism
adult: myxedema
hypothyroidism
primary
Hashimoto disease
iodine deficiency
secondary
pituitary adenoma
antithyroid antibodies
TRH stimulation test
secondary hypothyroidism
low: free T4
low; TSH
primary hypothyroidism
low: free T4
high: high TSH
primary hyperthyroidism
high: free T4
low: TSH
secondary hyperthyroidism
high: free T4
high: TSH
thyroid follicle
thyroglobulin
thyrotoxicosis
TPO inhibitor: carbimazole
follicular epithelial cell
T3, T4 to blood, MIT, DIT's iodine to recycle
pharmalogical (iodine escape)
endocytosis
TPO thyroid peroxidase: coupling of 2 iodotyrosines = iodothyronine (T3, T4)
TPO thyroid peroxidase: iodination of tyrosine = iodothyrosine (MIT, DIT)
Wolff-Chiakoff effect
TPO thyroid peroxidase: oxidation of iodine
Na/I symporter
autoregulation (Jod-Basedow effect)