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MEMBRANE TRANSPORT 2 (types of transporter (active transport (use variety…
MEMBRANE TRANSPORT 2
types of transporter
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uniporter
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transport rate 50,000 x greater than trans-membrane diffusion
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symporter
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sodium ions flow down their concentration gradient and glucose is transported up its concentration gradient
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primary active transport
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sodium potassium pump
3 Na+ out, 2 K+ in, per ATP
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sodium gradient generated by sodium-potassium pump (Na+-K+ ATPase) is the major source of energy for secondary active transport of glucose in intestinal cells
P-glycoprotein (Pgp)
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abundant in plasma membrane of drug-resistant cells
pumps compounds out of the cell up a concentration gradient using ATP as energy source
macromolecules
features
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very large molecules
mass > 1,000 Da (sometimes > 1,000,000 Da)
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