Please enable JavaScript.
Coggle requires JavaScript to display documents.
CYSTIC FIBROSIS INFECTION TREATMENT (PHARMACOKINETICS (NARROW THERAPEUTIC…
CYSTIC FIBROSIS INFECTION TREATMENT
PHARMACOKINETICS
Longer antibiotic courses
Higher doses
INCREASED clearance
INCREASED volume of distribution
High plasma concentration
NARROW THERAPEUTIC INDEX
Gentamicin
Amikacin
Tobramycin
Require drug monitoring
IV ANTIBIOTICS
Used for
Infective exacerbations
Sputum culture
Taken before starting treatment
Sputum induction
Nebulised hypertonic sodium chloride solution
Routine treament
Every 3 months
Chronically colonised with Pseudomonas aeruginosa
Administered
Hospital
Home
Antibiotic syringes
Sodium chloride 0.9% IV flushes
Heparin IV flushes
ANTIBIOTIC SELECTION
Patient's
Microbiological profile
Clinical symptoms
Resistance
Sensitivities
Acute infection can have different sensitivites to chronic infection
Antibiotic may not correlate to pathogen
Specialist area
At least 2 antibiotics
Aminoglycoside and a beta-lactam
NEBULISED ANTIBIOTICS
Used for
Routine treament
Every 3 months
Chronically colonised with Pseudomonas aeruginosa
Colistimethate
Monitor lung function before and after
Monitor
Bronchospasm
Repeat test using bronchodilator
Tobramycin
Admin. cyclical basis
28 day course / 28 day interval
Aztreonam