Please enable JavaScript.

Coggle requires JavaScript to display documents.

Neoplasia (BIOCHEMISTRY OF INTERCELLULAR AND INTRACELLULAR SIGNAL…

- - - - EGFR (ErbB1)
- - - - Growth Factor Receptor and Signal Transduction Antagonists:
        
        1. BCR-Abl/C-KIT/PDGFR Inhibition -tinib
        
        Second Generation:
        Nilotinib
        Dasatinib
        
        Third Generation:
        Bosutinib
        Ponatinib -inhibits VEGFR and FGFR family members in addition to ABL, SRC, and other kinases, has shown activity even in the resistant T315I population but is associated with increased vascular toxicity.
        
        First Generation:
        Imatinib
      - Proteasome Inhibitors:
      - Tumor-Specific Monoclonal Antibodies:
      - Monoclonal Antibodies:
        Rituximab - It lyses B lymphocytes by binding to the calcium-channel forming CD20 protein and activating complement
        Alemtuzumab
        Ofatumab
        Brentixumab
        Trastuzumab - oncogenic protein termed HER2
        panitumumab and cetuximab
        Bevacizumab -It neutralises VEGF (vascular endothelial growth factor), thereby preventing the angiogenesis that is crucial to tumour survival.
        Catumaxomab -attaches to an epithelial adhesion molecule, EpCAM, which is overexpressed in some malignant cells (e.g. malignant ascites in the peritoneal cavity). The antibody binds to this adhesion molecule and also to T lymphocytes and antigen-presenting cells, thus facilitating the action of the immune system in clearing the cancer.
      - Protein Kinase Inhibitors:
      - Angiogenesis Inhibitors
    - - 1. Alkylating agents
        
        Bis(chlorethyl)amines (nitrogen mustards): -ph(f)os-ph(f)amide
        Prototype: cyclophosphamide
        Others: mechlorethamine, chlorambucil, melphalan, ifosfamide
        
        Nitrosoureas: -mustine
        Prototype: carmustine
        Others: lomustine, semustine, bendamustine
        
        Aziridines (Ethylenimine):
        Prototype: thiotepa
        Others: triethylenemelamine
        
        Platinum coordination complexes:-platin
        Prototype: cisplatin
        Others: carboplatin, oxaliplatin
        
        Alkyl Sulfonate: -sulfan
        Prototype: busulfan
        Others: treosulfan
        
        Triazine: -carbazine
        Dacarbazine (DTIC),
        Temozolomide
        
        Methylhydrazine: -carbazine Procarbazine
      - 2. Antimetabolites
        
        Folate (analogues) antagonist:
        Prototype: Methotrexate (Mtx)
        Pemetrexed
      - 4.Antibiotics
      - 5. Anticancer drugs from plant origin
      - 3.Plant derivatives
  - - - Emetogenic potential of cytotoxic drugs:
        
        High
        Cisplatin
        Mustine
        Cyclophosphamide
        Actinomycin D
        Dacarbazine
        Lomustine
        
        Moderate
        Carboplatin
        Cytarabine
        Procarbazine
        Vinblastine
        Doxorubicin
        Daunorubicin
        Ifosfamide
        6-Mercaptopurine
        Paclitaxel
        
        Mild
        Bleomycin
        Chlorambucil
        Busulfan
        Fluorouracil
        6-Thioguanine
        Hydroxyurea
        Vincristine
        Methotrexate
        Etoposide
        l-Asparaginase