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A11 CML chronic myeloid leukemia (types (chronic phase (most), accelerated…
A11 CML chronic myeloid leukemia
types
chronic phase
most
accelerated phase
blast phase
acute myeloid/lymphoblastic leukemia
definition
Philadelphia chromosome
CML, ALL
chromosome 22: Ph chromosome
tyrosine kinase ABL1 to BCR
t(9:22)(q34;q11), BCR-ABL1 gene
reciprocal transloation
aetiology
clinical
cytogenetics
karyotype
FISH
PCR
BCR-ABL1 gene
flow cytometry
CBC
thrombocytosis
leukocytosis: basophilia
anemia
blood film
spectrum of myeloid cells
treatment
TKI tyrosine kinase inhibitor: imantinib
quantitative PCR
resistance: kinase domain mutation
bone marrow aspiration
spectrum of myeloid cells
hypercellular
