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Female Pharm (Sex hormones (BC pills (Both E and P, Combined pills treat…
Female Pharm
Sex hormones
BC pills
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E only- mestranol, ethinyl estradiol. Causes endometrial cancer
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ADR- hypercoagulability, gallbladder. Antibiotics decrease efficacy. Also antagonizes warfarin, increases cyclosporine, GCs, antidepressant levels
P only pills- Norgestrel, norethindrone. Don't menstruate. Used in long term implants too.
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Clomiphene
Blocks E receptors in brain, partial agonist of E receptors in ovaries
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Well tolerated- vision abnormalities, many births, OHSS
SERMs
Tamoxifen, Raloxifene (raloxifene better, no action at endometrium)
Used in breast cancer, hypogonadism
Activate in bone, antagonize breast/endometrium
GnRH agonists- used in endometriosis, also prostate/breast cancer
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Agonists- leuprolide, goserelin, naferelin
Antagonists- cetrorelix, ganirelix
Aromatase inhibitors
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Used in ER+ breast cancer, PCOS
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Dopamine agonists
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Bromocriptine, cabergoline
Androgen drugs
Danazole- agonist used in endometriosis, mixed action at progesterone receptor
Antagonists
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Spironolactone
also blocks aldosterone, K sparing diuretic. Can cause hirsutism.
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Progesterone antagonists
Mifepristone
abortificient, often combined with misoprostol
Levonorgestrel- blocks LH surge, Plan B