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Urinary system (Functions (Excretion (Ions (Hydrogen), • Urea • Uric acid…
Urinary system
Functions
Excretion
• Urea
• Uric acid
• Creatinine
Ions
Hydrogen
Toxins
Water balance
500ml/day urine required to clear waste
Electrolyte balance
• Sodium
• Potassium
• Hydrogen
Form pH buffer substances
PH balance
Lungs
Kidneys
Blood pH: 7.35-7.45
Blood sugar regulation
Renal threshold for glucose is 9mmol/L
Gluconeogenesis
Blood pressure
RAAS
The enzyme Renin
released by the kidney
into the blood
Renin converts
angiotensinogen to
angiotensin I (in Liver)
Angiotensin I
converted to
angiotensin II by ACE
Angiotensin II causes
release of Aldosterone
from the adrenal cortex
Aldosterone increases
renal sodium &
water absorption
Increased
blood pressure
Angiotensin II triggers
vasodilation & releases ADH
Increases blood pressure
ANP
Inhibits reabsorption of Na & water
Atrial stretch
Production of hormones
Erythropoetin
Erythropoeisis (hypoxia)
Calcitriol
Increases bone formation
Erythrocyte production
Hormones affecting
kidney reabsorption
Antidiuretic hormone (ADH)
Aldosterone
Atrial naturietic peptide
Parathyroid hormone
Angiotensin II
Components
2 kidneys
Layers
• Renal fascia
• Adipose capsule
• Renal capsule
Nephron
Renal corpuscle
Glumerulus
Bowman's capsule
Renal tubules
• Proximal convoluted tubule
• Loop of Henle
• Distal convoluted tubule
Internal structure
Renal cortex
Renal Medulla
• Renal pyramids
• Renal Papilla/Papillary ducts
• Renal pelvis
• Nephrons
• Hilum
• Blood supply
• Minor & major calyces
2 ureters
Bladder
Muscularis
Detrusor
Internal urethral sphincter (involuntary)
Trigone
Urethra
Urine formation
Glomerular filtration
Filtration pressures
• Blood pressure
• Osmotic pressure
• Hydrostatic pressure
Blood constituents
that remain in capillaries
• Leukocytes
• Erythrocytes
• Platelets
GFR
• Male 125ml/min
• Female 105ml/min
Blood constituents
that pass into filtrate
• Water
• Electrolytes
• Amino acids
• Glucose
Renal autoregulation
Damage to capillaries
Abuminuria
Oedema
Adapted for filtration
• Diameter of efferent
• Leaky capillaries
Tubular reabsorption
Tubular secretion
• Waste products
• Drugs
• Excess ions (H+)
Treatment
Dialysis
• Haemodialysis
• Peritoneal dialysis
ACE inhibitors
Diuretics
Urine flow
Micturition
Urine composition
Examinations
Urinalysis