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Thymus (Th0 (paracortex) (Th2 (IL-4 (M2 Macrophages (Debris removal,…

- - - - M1 Macrophages
        
        TNF-alpha, IL-1
        
        Inflammation
        
        E-Selectin (Endothelial cells)
        
        Binds Sialyl Lewis X (Leukocytes)
        
        CAMs (Endothelial cells)
        
        Integrins (Leukocytes)
        
        Promoted by LTB4, C5a
        
        IL-12
        
        Th0 --> Th1#
  - - - M2 Macrophages
        
        Debris removal, scarring, walling off pathogens
      - Class switching: IgG, IgE
      - Eosinophil chemotaxis
    - - Class switching: IgA
      - B cell --> Plamsa cell
      - Eosinophil chemotaxis + activation
    - - Inhibit Th1
  - - - M1 Macrophages, Monocytes (vigorous stimulation)
  - - - Inhibits Macrophages
    - - Inhibits MHC Class II (Macrophages, DCs)
  - - - Plasma cell
        
        IgM
        
        IgG
        
        IgA
        
        IgE