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Fat:endocrine (Hypothalamus (Arcuate nucleus (ARC) (Anorexigenic:
POMC…
Fat:endocrine
Hypothalamus
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Arcuate nucleus (ARC)
Anorexigenic:
- POMC (proopiomelanocortin)
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Orexigenic neuropeptides
- NPY (neuropeptide Y)
- AgRP (agouti-related peptide)
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3rd ventricle, above median eminence
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Adipose tissue
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Brown
- Transfer energy from food into heat
- Lipid utilization
Leptin
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- Cleaved to produce mature leptin
- Leptin acts via ObRb to regulate body weight
Leptin:
- DECREASE FOOD INTAKE
- INCREASE ENERGY EXPENDITURE
- Passes BBB
- binds to ObRb
- Increase POMC
- Decreases NPY/AGRP
Stomach
Ghrelin
- Orexigenic hormone:
- iNCREASE FOOD INTAKE
- Ghrelin receptor (GHS-R) in brain
- Stimulates feeding via activation
- increase in NPY/AgRP
- Decrease POMC
NEURONAL ACTIVITIES
Small intestine
GLP-1
- increase insulin, decrease glucagon
- decrease food intake
- GLP-1 receptor agonists
Pancreas
Insulin
- Highly expressed in CNS
- Anorexigenic effect
- Increase POMC and decreases AgRP gene expression in ARC