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Innate Immunity (Major Functions: Killing microbes and activating adaptive…
Innate Immunity (Major Functions: Killing microbes and activating adaptive immunity)
Pattern-recognition receptors
LPS
Manna-binding lectin (MBL)
Acute- Phase Response
Macrohphages
Phagocytosi s
Antigen Presentation
Cytokine production
Dendritic Cells
Presents antogen to CD4 T cells
Natural Killer Cells
Kill virus infected cells and killer cells
Recognize absence of MHC
Produces IFN-gamma
Can be activated by IL-2 and IFN-gamma
Neutrophils
Phagocytise bacterial cells
First line of defense-arrive first at thesite
Do not present antigen to T Cells
Monocytes
They live in blood
Arrive later than neutrophils at site of infection
Complement
Baophils and Mast Cells
Involved in inflammation
Mast cells release histamine
Release biologically activate proteins
Eosinophils
Important in parasitic disease and allergies
Cytokines
IFN-alpha and IFN-beta
Produced by fibroblass, epithelial cells and leukocytes
Inhibits viral replication
Activates NK Cells
Increases MHC 1
IL-1
Produces by macrophages
Enhances response of lymphocytes
Induces acute-phase protein secretion in the liver
IL-6
Produced by macrophages and dendritic cells
Enhances the response of lymphocytes
Induces acute-phase protein secretion
IL-12
TNF-alpha
Produced by macrophages and dendritic cells
Induces changes in vascular endothelium
Chemokine CXCL8/ IL8