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Foundation (germ, stem and somatic (Stem: -divide indefinitely -rise to…

- - - - Proteins: turn specific genes on or off by binding to nearby DNA
      - Activators or repressors
      - Groups of transcription factor binding sites called enhancers and silencers can turn a gene off or on
- - - - ASD:
        CFD trigger cell fate decision
        Proteins, mRNA, aged mito
        Stem cell potential reatained or lost during ACD or SCD
      - Balances proliferation and self-renewal with cell cycle exit and differentiation
  - - - Stratum corneum
        stratum lucidum
        stratum granulosum
        stratum spinosum
        stratum basale
      - Squames:
        flat membranous sac filled with keratin, no nucleus-barrier
        Melanocytes:
        activate tyrosinase, form dendrites, UV protection
        Langerhan Cells
        monocyte: immune
        Merkel:
        Epithelial lineage: synapse like contact
        
        Melans:
        -Basal layer
        -differentiate: emb development
        -G0 permanently
        -modify exoskeleton: dendrites
        -melanosomes: SER, RER and golgi
        
        melanin: tyrosinase
        taken up by keratinocytes: endocytosis
        lysosomes in keratinocytes degrade melanin
        
        Merkel:
        skin region, high tactile acuity
        signal static stimuli: pressure
        expression of distinct keratins
      - Protection:
        barrier: stratum corenum
        Immune defense, langerhan, stratum spinosum
        pigement: melanocytes
        Sensation:
        merkel: stratum basale
        Cont of evap:
        semi impermeable barrier to fluid loss
        Storage and synthesis:
        synthesis Vit D: SB and SS
        Absorption
      - Water resistance:
        sabaceous glands
        Cont of evap:
        semi impermeable + sab
        Sens:
        temp, touch, pressure
        Heat regulation:
        dilation/cons of blood vessels
        hair erection
        sweat
        Excretion:
        sweat, urea