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molecular 2 (response (complete hematological response (more sensitive…
molecular 2
response
complete hematological response
more sensitive than cytogenetics: MMR resistance: inc BCR-ABL1
complete cytogenetic response
major molecular response
mutation
CEBPA :smiley:
NPM1 without FLT3 :smiley:
FLT3
FLT3 inhibitor
e13a2/e14a2
x
atypical, PCR
v
RQ-PCR
CML: molecular monitoring
ph chromosome
BCL-ABL1
e14a2
reverse transcription pcr
e13a2
monitoring
plasma level
tki: imantinib
resistance
primary refractoriness: start
efficacy
acquired resistance: later
resistance
BCR-ABL1 kinase domain mutations/gene amplifications
inc BCR-ABL1
x imantinib x nilotinib x dasatinib
v nilotinib
v dasatinib
AML: genetic profiling