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Cell-Cell interaction (Cell adhesion and intercellular junction (gap…

- - - - mesenchymal cells
- - - - nature of ECM defines characters of connective tissues
  - - - Mutation
        
        brittle bones ( loss of triple helix)
        
        ehlers donlas syndrome ( fault in assembly of cross linking of collagen fibers )
    - - Mutation
        
        marfan syndrome (dominant mutation in one of genes coding for elastic fibers)
    - - GAG (glycoaminoglycans)
      - proteoglycans (GAG, core protein)
        
        aggregate cartilages
        
        chemical signaling
    - - laminin
        
        basal lamina
        
        Mutation
        
        alport syndrome ( type IV mutation collagen gene)
      - fibronectin
        
        embryotic development
        
        cell attachment
        
        wound healing