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Inflammation
Inflammation
neutrophil extravastation
stasis-->rolling-->binding--> extravastation-->chemotaxis
stasis
rolling
P-selectin
low affinity
binding
integrin (LFA1)
high affinity
extravastation
chemotaxis
Classical Sign
Redness
Swelling
Heat
Pain
Outcome
Abscess
collection of pus (neutrophils & necrotic debris)
Resolution
Scarring
Chronic inflammation
Type
Acute
Mast cell
release histamine
activated by C5a, trauma/injury, cold, heat
Prostagladin D2
vasodilator
causes pain
prevented by NSAID
Chronic
anti-inflammatory cytokine
IL-10
TGF-B
secreted by marcophages
Definition
extravascular accumulation of plasma proteins & leukocyte