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Hemostasis (INHIBIT Coagulation (Injectable anticoagulants (Non…

- - - - HERUDIN
        
        From leeches is the most potent inhibitor of thrombin known.
      - HIRUGIN
        
        Small peptide derived from Hirudin
    - - Inhibits the thrombin III-mediated conversion of
        fibrinogen to fibrin
        
        Inhibits the aggregation of platelets by thrombin
        
        Inhibits activation of fibrin stabilizing enzyme
        
        Inhibits activated factors XII, XI, IX, X , VII.
        
        Activation of heparin cofactor II - specific anti- thrombin.
  - - - RETEPLASE : Longer half-life than Alteplase
      - ALTEPLASE
        
        Short half-life
        
        High cost
        
        High clot selectivity
      - UROKINASE : Used primarily for clearance of catheters
    - - STREPTOKINASE: Used in MI
  - - - Decarboxy- prothrombin
        
        Inhibit regeneration of vitamin K
        
        Decreases synthesis of the vitamin K-dependent clotting factors II, VII, IX, X
        
        Decreases the activity of protein C (activated by thrombin)