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CRF (definition (risk factor (:star:diabetes, hypertension :,…

- - - - 減少po4排出
      - 減少renal ammonia合成
    - - retention of organic acid
  - - - restrict dietary phosphate,an active D analogue,use phosphate binder
      - hyperphosphatemia
        
        increase parathyroid hormone
        
        inhibit 1,25 vitamine D synthesis
        
        increase fibroblast
        
        Direct vascular injury
        
        drug interaction with phosphate binder
        
        drugs:calcium carbonate,calcium acetate與磷酸跟結合
  - - - smoking
      - sodium intake diet:<2.4g per day
      - weight
      - hypertension:<130/80mmHg
      - DM
      - Anemia
- - - - 減少diatery protein
        
        降至0.8-1.0 per kg of BW
      - ACEI+ARB:worsen renal outcomes
      - 300-500mg/per day
    - - slow the rate of progression of CKD: ACEI,ARB-first line choice
      - lower than130/80