Blood and hemopoesis
A Coggle Diagram about Blood coagulation
- Blood coagulation contributes to homeostasis and is strictly controlled so coagulation only occurs in damaged vessels.
- Coagulation factors necessary for coagulation are activated and undergo a cascade of reactions.
- The platelets membrane and Calcium ions (factor IV) are also required
- Hemophilia A is characterized by factor VIII deficiency, which in severe cases causes excessive bleeding and hemarthrosis
- CFU - MEG
- Endomitosis --> 64 nuclei
(Postnatal hemapoiesis involves three classes of cells: stem, progenitor and precursor cells.
, Blood formation: Stem cells
- Prenatal hemopoiesis is done through yolk sac, liver, spleen and bone marrow.
- The bone marrow joins in after about 6 months with an increasing role.
- The liver and spleen stop hemapoiesis at the time of birth
), General characteristics
, Blood components
), Bone marrow
- Red marrow in adults is located in the epiphysis of long bones, and in flat, irregular and short bones. It is highly vascular and consists of a stroma (with stromal cells), irregular sinosoids and islands of hemopoietic cells.
- Red marrow is where megakaryocytes are located and where erythrocytes are differentiated and maturated.
- Yellow marrow is located in long bones of adults and is highly infiltrated with fat. Is NOT hemopoietic but can become if necessary.
) and Leukocytes
- Leukoctes possess azurophilic granules that are lysosomes containing hydrolytic enzymes
- Granulycytes include neutrophils, basophils and eosinophils
- These cells possess specific granules depending on which cell it is.
- ATP is formed through glycolisys, krebs cycle (basophils) and anaerobic pathways (only neutrophils)