Obesity - Brainstorm 2

Adipose Tissue

Nanoparticle coated drug w/ external magnetic delivery system

Liposuction

Target pannus

Optogenetic control

WAT-specific induction of adiponectin

Leptin

Lasers

Reverse program adiopose cells

Co-deliver with other hormones

Induce release from adipose cells

Leptin-like molecule

Drug therapy

Leptin supplements during weight loss

PVAT inflammation

Increase lipolysis

Adipose melting

Immunotherapy

Brown fat injection

Adipose eating bacteria

Freeze adiopose cells

Mimic traits of exercise conditioned WAT in obese patients' WAT

Metabolism

Targeted hormone therapy

Genome sequence for hormone-loop interrogation

Hormone monitoring implant

Dynamic model of hormone signalling

new proteins that interrupt hunger cycle

Ice vest

Electro-stimulation of hypothalamus

Cold-mimicking neck bands

Artificial programmable hypothalamus

Stomach

Stomach pump

Stomach pacemaker

Induce stomach to release carb-blocking enzyme

stomach fullness sensor

Optimized GES

Inhibit ghrelin release from stomach

Combine short/long pulse GES

Duodenal sphincter valve

Reduce stomach emptying rate

Dynamic gastric band

Lower GI

Electro-stimulation

duodenal obstruction (balloon)

duodenal mesh

malabsorptive carb-binding agent

GI pacemaker

GI nerve inervation

intestinal sleeve

behavioral therapy

social networking platform

hypnosis

high grav chair

sleep hormone imbalance

individualized diet/exercise plan

augmented reality calorie counting

sensors for eating

calorie counting smart plate

caffeine/alcohol regulation

Hormones

Target downstream effects of leptin resistance

Restore leptin sensitivity

Leptin/ghrelin sensor + watch

Leptin/ghrelin sensor pumpp

POMC/CART neuron activator

Study structure of leptin-response ion channels and predict drugs

Increase leptin delivery to brain

Increase leptin receptors

CCK upregulation

Ghrelin inhibitor or receptor blockers

Smart CCK pump

Pill filled with molecules that mimic food particles binding to receptors in stomach lining

Ghrelin/leptin model to predict resistance (ODEs)