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Peripartum Cardiomyopathy (Risk Factors (History of postpartum…
Peripartum Cardiomyopathy
Risk Factors
History of postpartum hypertension
history of eclampsia
Pregnancy with multiple fetuses
maternal cocaine abuse
African Descent
Extra pumping of blood during pregnancy
Greater than 30 yo
obesity
Poor nutrition
inflammation in the heart
viral illness prior to pregnancy
abnormal immune response
coronary artery spasm
small vessel disease
defective antioxidant system
smoking and alcoholism
Symptoms
Palpitations
Chest pain
Excessive fatigue
Shortness of breath
Increased night time urination
Swelling of the ankles
Suspected Pathophysiology
Inflammatory cytokines
inflammation of the pericardium
Peripartum Cardiomyopathy
Dilation of ventricles
decreased contractilty of the left ventricle
Decrease stroke volume
Decrease cardiac output
Increase in sympathetic output
3 more items...
Altered prolactin processing
endothelial damage and myocardial dysfunction
Abnormal Immune Response
Fetal cells escape into the maternal circulation
Cells lodge into cardiac cells
Trigger pathologic immune response
Angiogentic imabalnce
Altered angiogenic factors
Poor vascularization
Hemodynamic factors
Increase in blood production during pregnancy
Left ventricle remodeling