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Lymphatic System (Tissues & Organs (Lymph nodes (Cortex (Superficial…

- - - - Trabecula
      - Trabecular sinus
      - Superficial cortex
        
        Germinal center
      - Deep cortex (paracortex)
        
        HEV
    - - Medullary sinuses
      - Medullary cords
    - - Subcapsular sinus
  - - - Bronchus-associated lymphatic tissue (BALT)
      - Tonsils (pharyngeal, palatine, lingual)
      - Gut-associated lymphatic tissue (GALT)
      - Peyer's patch (ilium)
      - Vermiform appendix
  - - - Epithelial reticular cells (erc) I~VI
      - Fully functional at birth
      - Lymphoepithelial organ
      - Starting involution after puberty
      - Thymic (Hassall's) corpuscles
      - Blood-thymus barrier
        
        Endothelium
        
        Macrophages
        
        Type I erc
      - T-cell education-DN➞DP➞PS➞NS➞SP
    - - Cortex
        
        Type I erc
        
        Double negative (CD2, CD7)
        
        Double positive (TRC, CD1, CD2, CD3, CD7, CD4, CD8)
        
        Positive selection (Type II erc)
        
        Type III erc
      - Medulla
        
        Type IV erc
        
        Negative selection (Type V erc)
        
        Single positive
        
        Type VI erc (Hassall's corpuscle)
      - Capsule
  - - - Immune functions
        
        Activation and proliferation of lymphocytes
        
        Ags presentation and immune response
        
        Abs production
        
        Removal of macromolecular Ags
      - Hemopoietic functions
        
        Retrieval of iron from Hb
        
        Removal and destruction of aged blood cells
        
        RBC formation and blood storage
    - - Capsule
        
        Trabecula
      - White pulp
        
        Central artery
        
        Periarterial lymphoid sheath (PALS)
        
        Splenic nodule (Malpighian corpuscle)
        
        Germinal center
        
        Marginal area
      - red pulp
        
        Splenic sinuses
        
        rod-shaped endothelium
        
        Splenic cords (Billroth cords)
        
        open circulation
- - - - Cytotoxic CD8+ lymphocytes
      - Regulatory (suppressor) T lymphocytes
      - Helper CD4+ lymphocytes
        
        TH2 cells
        
        TH1 cells
      - 𝛄/δ T lymphocytes
  - - - NK cell
    - - Hemopoietic stem cells (HSCs)
    - - Mainly for B cells
    - - All human leukocytes
    - - Mainly for T cells
    - - Antigen-presenting cells (APCs)
  - - - Become immunocompetent cell
      - At primary lymphatic organ
        
        Bursa-equivalent organ
        
        Bone marrow
        
        Gut-associated lymphatic tissue
        
        Thymus
    - - At secondary lymphatic organs
        
        Tonsils
        
        Spleen
        
        Lymph nodes
      - Become effector and memory cells