Please enable JavaScript.
Coggle requires JavaScript to display documents.
Phosphodiesterases (PDEs) (Structure (N-terminus (F: membrane associations…
Phosphodiesterases (PDEs)
Functions:
regulate the localization, duration, and amplitude of cyclic nucleotide signaling (regulators of signal transduction)
Substrate specificity
cAMP
PDE4, PDE7, PDE8
cGMP
PDE5, PDE6, PDE9
dual
PDE1, PDE2, PDE3, PDE10, PDE11
Term
enzymes that breaks a phosphodiester bond.
Families
PDE1-11
PDE4
Localization
membrane-bond/cytosolic
main functions:
memory formation
monocyte and macrophage activation
fertility
drugs
Ruflumilat
Gebr-7 and Gebr-32a
rolipram
Structure
N-terminus
F: membrane associations; localization
Catalytic domain
F: substrate specificity; inhibitor sensitivity; metal binding sites
regulatory domain
F: phosphorylation sites;dimerization domain
C-terminus
Anchoring domain