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tc2 micro (hematology (hemorrhagic fever (Lassa (Arena virus
ROBA
carry…
tc2 micro
hematology
bloodstream parasite
plasmodium
- falciparum
- vivax, ovale
- malariae
-
-
-
anemia
-
parasite
- diphyllobothrium latum: tapeworm - >macrocytic (competes vitB12 in jejunum)
- hookworm (necator americanus)->microcytic
angiomatosis
- henselae: cat scratch; flea fece
- quintana: HBlouse (feces)
- HIV+: angiomatosis
-
hemorrhagic fever
-
Lassa
Arena virus
ROBA
- carry ribosome (sandy look)
-
Yellow fever
(renal x, hepatitis)
-
-
relapsing fever
Borrelia
- recurrentis:human body louse, one lapse
- hermsii: animal(Rodent)-tick, 3-10 lapse
Immune system
immune cell
-
Monocyte/mac
-
bacteria
- brucella abortus, melitensis, suis
- coxiella burnetti
- ehrlichia caffeensis/anaplasma
-
Lymph Node
-
-
-
-
-
- sporothrix schenckii (fungi)
lymphatic filariasis
- wucheria bancrofti
- brugia malayi
PNS
demyelinating
campylobacter jejuni
- guillain barre
- peripheral/CN
-
-
-
focal brain lesion
taenia solium (cestode;tapeworm)
- eat larvae (undercooked pork) ->worm (human=def host)
- eat egg -> larvae (cysticerci) (human = intermediate)
- cysticerci in brain (epilepsy, hydrocephalus, eosinophilia, calcified granuloma)
Taxoplasma gondii
- cat poop oocyst
- undercooked tissue cyst (filled w/ bradyzoite)
- transplacental transfer of tachyzoite
- tachyzoite (ooycsts/tissue cyst transforms into) localize -> tissue cyst (bradyzoite, Ab+)
- Ab+ AIDS, CD4<100 -> chorioretinitis. ring enhancing lesions
Myelitis
picornavirus
Encephalitis
parasitic
trypanosoma brucei
- antigenic variation, high IgM
- rhodesiense: early
- Gambiense
-
Acanthaoeba
- soil/water, inhale cyst
- spiky trophozoite
- GAE (chronic) in immunocomp
Naegleria fowleri
- ameba in water, trophozoite -> nasal passage
- PAM (bi-frontal cortex) acute
-
HSV
- 1: sporadic, temporal lobe
- 2: global neonatal
-
-
-
psittaci
- parrot (poop) fever (atypical pneumonia)
-
-
Polyoma
- JC polyoma
- early: polyoma T antigen, inactivate p53, p105RB
measles
- SSPE (<2yr old highest risk, occurs 7-10 yr after infection, myoclonus/spasticity. demyelinate brain)
- measles encephalitis: direct neuronal infection (5d after rash)
- post-infectious ADEM: autoimmune response (<2weeks of rash)
-
La Cross (US, non fatal encephalitis
-
Reovirus: Coltivirus
generalized rash, myalgia ~week
Enterovirus (Fecal oral)
- coxackie & echo
- most common cause of viral meningitis
-
- D68: severe resp dz
- A71: hand-foot-mouth dz (also meningitis in young child)
-
polio
- paralytic myelitis: asymmetric flaccid paralysis, no sensory loss
- bulbar poliomyelitis (CNs, medullary respiratory center)
- oral polio vaccine (life, attenuated) can revert and cause paralytic dz. We now use IPV