Myocardial Infarction

Poor Dietary choices

Poor sleeping habits

Lack of physical activity

Poor coping habits from stress

increased fatty acid and cholestrol intake

Increased blood pressure

Increased adiposity

Dys-regulation of the immune system

Increase inflammatory markers in circulation

Increased blood viscosity

Increase BP

Constriction of blood vessels

Increase in turbulent flow

Shearing of endothelium

Depositing LDLs in endothelium become oxidized

WBCs attack the LDL deposits by releasing inflammatory cytokines to break down the deposit

WBC phagocytose deposit and turns into foam cell

Foam cell stimulate collagen and other matrix production

attracts more T cell and macrophage action

Plaque grows in size

Increase in turbulence and shear of vessel

Development of athlerosclerotic plaque in coronary artery

Increase BP

Occlusion of the coronary artery

Increased workload of the heart

Decreased blood supply

Greater demand for oxygen

Ischemia of the myocardium

cardiac cell function diminished

Cellular necrosis

Myocardial Infarction

Partial thickness MI/ Non-STEMI

Further cell necrosis

Full thickness/ transmural MI/ STEMI

Signs on EKG

ST segment elevation

Signficant Q waves

Significant Q wave

Inverted T wave

Symptoms

Extreme pressure/tightness over sternal region

Radiating pain to jaw, upper back & shoulders L>R

SOB

Nausea

Lightheadedness

Diaphoresis

Pallor

Medical Management

CABG

Angioplasty with stent

Medications

ACE inhibitors

Beta Blockers

Nitroglycerin

Calcium Channel Blockers

Diagnosis

EKG

Tropinons

CPKs

Angiogrpahy