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Receptor Theory (quantitative aspects of drug-receptor interactions…

- - - - certain safety factor (CSF) : LD1/ED99; use for when two dose ranges are more similar; ratio > 1 = good; therapeutic dose for 99% of pop < lethal dose for 1% of pop
      - therapeautic index = LD50/ED50 high therapeutic index = good
- - - - shift curve to the right; increases ED50 of agonist drug
      - no change in efficacy
      - = most antagonists
    - - covalent binding
      - decreased efficacy; shift curve down
      - toxins
  - - - butyrylcholine = partial agonist, compared to priopionylcholine and acetylcholine
- - - - allosteric antagonism
      - pharmacokinetic antagonism
      - signaling blockade
      - physiological antagonism
  - - - one drug prevents metabolism/breakdown of second drug: ampicillin + sulbactam :
        sulbactam = weak antibacterial, inhibits beta-lactamase; prevents beta-lactamase from breaking beta-lactam ring of ampicillin
      - drugs target different molecules on same signaling pathway to enhance downstream effect