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Anti-Coagulants By Route of Entry (Oral (Direct Thrombin Inhibitor…
Anti-Coagulants
By Route of Entry
IV or Subcutaneous
HMW Heparin
IV = immediate onset
1/2 life 50-150 min
Subcutaneous
LMW Heparin
IV
Direct Thrombin Inhibitors
Lepirudin
Bivalirudin
Argatroban
(Continuous IV infusion only)
Reversing Anticoag Effects
Protamine Sulfate
:red_cross:Heparin
Idarucizumab
:red_cross:Dabigatran (direct thrombin inhib)
Factor Xa
Fibrinolytic Agents
Atelplase / tPA
Reteplase
Tenecteplase
(single IV bolus)
Urokinase
GPIIb/IIIa Receptor Inhibitors
Abciximab
Tirofiban
Eptifibatide
Oral
Direct Thrombin Inhibitor
Dabigatran
Direct Factor Xa Inhibitor
Rapid onset, short half-life
Rivaroxaban
Apixaban
Edoxaban
Betrixaban
Warfarin
Reversing Anticoag Effects
Vitamin K
(Oral & Parenteral)
:red_cross:Warfarin
ADP-Induced Platelet Aggregation Inhibitors
Clopidogrel
Ticlopidine
Prasugrel
Ticagrelor
Cilostazol
PDE-3 Inhibitor
intermittent claudication
Vorapaxar
(protease activated receptor 1 antagonist)
Previous MI or PAD
Oral or IV
Antifibrinolytics
Bleeding Disorders
Aminocaprotic acid
Tranexamic acid
Dipyridamole
:red_cross: adenosine deaminase, phospho-diesterase