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MM14 - genetics 2, cytogenetics, human chromosomes + chromosomal disorders…

- - - - chromos 14 + 21
      - if parent is t(14:21) carrier...
        
        still diploid
        
        possible offspring:
        
        trisomy 14
        
        monosomy 14
        
        monosomy 21
        
        trisomy 21
        
        normal
        
        also carrier
- - - - uniparental disomies (2 chromos from same parent or part of chromo from 1 parent and no copy from the other)
        
        paternal = Prader Willi Syndrome
        
        facial dysmorphism, obesity, short, mental handicap
        
        maternal = Angelman Syndrome
        
        seizures, jerking, severe mental handicap
      - different phenotype depending on maternal or paternal inheritance