Can I control my addictive behaviour?

Cognitive neuroscience of addiction

dysfunction in cognitive systems and their relationship too symptoms of addiction

policy implications

Question of whether addiction is a disease that causes symptoms or if there are differences in neurobiology that cause someone to be more susceptible.

drugs over activate pleasure centres of the brain/limbic systems

release dopamine via nucleus accumbens

closely associated with learning systems--> association of pleasure with drug related stimuli

strength of cravings associated with level of cue-related activation of limbic system

predictor of relapse

Methamphetamine

chronic use associated with several cognitive impairments

decreased EF

poor verbal memory

slowed processing speed

poor self control

reduced selective attention (more distractible)

decision making is biases towards immediate gratification

decreased cognitive flexibility (switching between tasks)

Use behaviour, frequency, quantity etc does not predict degree of impairment

potentially predicted by individual susceptibility

insula cortex critical to awareness of cravings

damage to this region increases likelihood of quitting

Low availability of D2 receptors--> high susceptibility to addiction

click to edit

drug induced increases in DA lead to optimal level of stimulation in people with low amounts of receptor. In those that have high amounts--> unpleasant experience of drugs

level of dopamine metabolism depletion worsens in chronic MA users

leads to high risk of developing parkinsons

predictor of relapse

associated with greater impulsivity for reward

Taq1A is gene that controls D2 receptor levels in brain, 2 copies leads to decreased D2 receptors

Direct stimulation eg drugs or indirect eg gambling

associated with likelihood of developing an addiction

Dopamine and self control

Parkinsons

associated with decreased IC and low dopaminergic tone

Habits

Impulsivity for reward

Acknowledged by DSM-V criteria for substance use disorder

loss of control is relative

Inhibitory control

top-down processing

anterior cingulate cortex detects need for IC

dorsolateral prefrontal cortex implements top-down control

amplify neural representations of task relevant stimuli

inhibit task irrelevant stimuli

repeated responding that forms context related associations

automatic responses that are relatively insensitive to changes in reponse

different to goal related repetitive behaviours as habits not always associated with goals as outcomes

habits persist even when positive outcome no longer occuring

repeated behaviour over time becomes less goal directed

formation initially based on rewards

maintenance associated with context cues (associated with reward)

interval schedules particularly effective

grow accustomed to behaviour not always resulting in award

premorbid risk

children of drug dependant ind. can have neurological deficits in Ic

drug related stimuli

attentional bias for drug related stimuli