Please enable JavaScript.
Coggle requires JavaScript to display documents.
11.MACROLIDE (things to remember (1st line indication (atypical bacteria…
11.MACROLIDE
things to remember
potent inhibitor of cytochrome P450
clarithromycin
QT prolongation
torsades de pointes
better tissue penetration than ery
erythromycin
QT prolangation
torsades de pointes
can pregnant
drug2 interaction
jangan pakai drug yg metabolised dkt CP450
if nak juga, pakai azitromycin
debilitating myopathy (muscle weakness)
macrolide + statin (lower cholesterol)
azitromycin
better tissue penetration than ery
x cardiac problem
1st line indication
atypical bacteria
acquired pneumonia
pen. & cepha allergic
H. Pylori
chlamydia (STD)
acute non-specific urethritis
coverage
erythromycin
B-hemolytic streptococci
penicillin-sensitive streptococcus pneumoniae
methicillin-sensitive staph. aureus
meningitis
gonorrhea
pertussis
campylobacter jejuni
treponema pallidum
ureaplasma urealyticum
mycoplasma pneumonia
Legionella pneumonia
corynebacterium diphtheriae
corynebacterium minuitissium
listeria monocytogenes
entamoeba histolytica
chlamydia sp.
rickettsial sp.
weak against haemophilus injluenzae
clarithromycin
mcm eythromycin
haemophilus influenzae
moraxella catarrhalis
mycobacterium avium-intracellulare (MAC)
non-tuberculous
atypical mycobacteria
in vitro against toxoplasma gondii
borrelia burgdoiferi
babesia microti
azithromycin
further expansion
legionella sp.
atypical mycobateria (except M.leprae)
bartonella henselae
rhodococcus eui
toxoplasma
cryptosporidium
plasmodium sp.
roxithromycin (new)
penetrate & accumulate within cell
utk intracellular pathogens
treatment
erythromycin
mycoplasma pneumoniae
legionella pneumophila
diphteria
pertussis
bacillary angiomatosis
chlamydia pneumonia
conjunctivitis
alternative for penicillin
campylobacter sp. diarrhea
alternative tetracycline utk preggy mommy
for pelvic inflammatory disease
clarithromycin
acute uper & lower resp tract
mild-moderate soft tissue
helicobacter pylori
toxoplasma infection
babesiosis
bacillary angiomatosis
spirochetal infections
paediatric
sinusitis
acute otitis media
pneumonia
grp A streptococcal pharyngitis & tonsillitis
streptococcal & staphylococcal skin infection
x preggy mommy
azitromycin
middle ear infections
strep throat
pneumonia
traveler's diarrhea
intestinal infection
STD
gonorrhea
malaria
.+ other drug
spectrum (broad, shallow antibacterial activity)
some G+ve
some G-ve
many atypical bact.
s/e
abnormal change to electrical activity of heart
(fatal) iregular heart rythm
GI toxicity
short half-life
limited antibacterial spectrum
bacteriostatic (utk x severe)