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nephritis path (anti-GBM (pathogenesis, histology, immunofluorescence),…
nephritis path
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lupus nephritis
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dsDNA very specific for lupus nephritis, ANA positive is less specific
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nephrotic path
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membranous nephropathy (aka membranous glomerulopathy, membranous GN)
histologic findings
subepithelial/intramembranous deposits (against the podocyte), causes GBM changes.
silver stain only marks collagen IV of GBM, so there are spaces between spikes. These are not actual spaces, but deposits that are visualized on trichrome staining.
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